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Contributed to natural product synthesis and synthetic methodology. His work ushered in a new era in total synthesis where practicality and simplicity are the focus, eschewing protecting groups, functional group manipulations, and non-essential redox manipulations. Several of his total syntheses are now being adopted for commercial production. His contributions in methodology center around practical C-H functionalization reactions and have had a remarkable impact based on actual drug candidates brought into the clinic using these methods and the sales of numerous reagents he has commercialized for use in the pharmaceutical industry.